Pancreatic Cancer 12-078

January 03, 2017

Sponsor: Memorial Sloan Kettering Cancer Center

Number: 12-078
Gemcitabine is a drug which is routinely used to treat pancreatic cancer, but many patients still succumb to the disease. In this study, researchers want to evaluate the safety and effectiveness of combining an investigational drug called M402, a blood thinner, with gemcitabine in patients with previously untreated metastatic pancreatic cancer. In this study, a modified form of M402 (which has less blood-thinning properties) is being used, and laboratory studies have shown that it has anticancer effects. The goal of the initial part of the study is to find the highest dose of M402 that can be given safely with gemcitabine in patients. M402 is an injection that patients (or their caregivers) can give themselves at home. Gemcitabine is given intravenously in the clinic.

Who’s eligible: Patients must have previously untreated metastatic pancreatic adenocarcinoma. Patients with blood clotting disorders and those on blood thinners may not be able to participate. Patients must be physically well enough that they are fully ambulatory, capable of all self care, and are capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.

Patients must be age 18 or older.

Available at: MidState Medical Center, The Hospital of Central Connecticut, Hartford Hospital.