Multiple Myeloma - Amgen

Compare efficacy of 56 mg/m2 carfilzomib administered once-weekly in combination with lenalidomide and dexamethasone (KRd 56 mg/m2) to 27 mg/m2 carfilzomib administered twice-weekly in combination with lenalidomide and dexamethasone (KRd 27 mg/m2) in subjects with relapsed or refractory multiple myeloma (RRMM) with 1 to 3 prior lines of therapy.

Eligibility Criteria

• Documented relapse or progressive multiple myeloma on or after any treatment (subjects refractory to the most recent line of therapy are eligible, unless last treatment contained PI or lenalidomide and dexamethasone).
• Subjects must have at least PR to at least 1 line of prior therapy.
• Subjects must have received at least 1 but not more than 3 prior lines of therapy for multiple myeloma (induction therapy followed by stem cell transplant and consolidation maintenance therapy will be considered as 1 line of therapy).
• Prior therapy with a PI or lenalidomide and dexamethasone is allowed, as long as the patient had at least a PR to most recent therapy with PI or lenalidomide and dexamethasone, was not removed due to toxicity, and will have at least a 6-month PI or lenalidomide and dexamethasone treatment-free interval from last dose received until first study treatment. (Patients may receive maintenance therapy with lenalidomide during this 6-month PI or lenalidomide and dexamethasone treatment-free interval).

This study is for patients age 18 Years to 70 Years   (Adult, Older Adult).

Available at: Hospital of Central Connecticut