Research News

Full AAHRPP Accreditation for the Hartford HealthCare Human Research Protection Program

The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP) recently awarded the Hartford HealthCare Human Research Protection Program (HRPP) the designation of Full Accreditation for a period of five years. This is an important achievement and reflects the commitment of our organization and Institutional Review Boards to protect the rights and welfare of Hartford HealthCare research participants. The Council also recognized our program’s innovative practices with an Area of Distinction award. The award acknowledged the development and implementation of a noncompliance tracking system which allows our HRPP team to continuously monitor the frequency and type of noncompliance events. These metrics are utilized to institute targeted education and changes in practice.

Dr. Michael Stevens Receives $3.7M Grant for ADHD Research

The National Institute of Mental Health has awarded a $3.7M research grant to Dr. Michael Stevens at the Olin Neuropsychiatry Research Center to test a new computerized cognitive training intervention for teens diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD).  This two-phase, 5-year clinical trial will test whether ADHD symptom severity can be reduced following a month of near-daily cognitive training sessions.  This study is based on recent neuroscience discovery of how specific ADHD brain function abnormalities seem to be improved through a particular focus of cognitive training.  The intervention targets the way specific frontal lobe brain regions communicate with other brain regions engaged to hold and manipulate information in mind that prior research has linked to ADHD symptom expression.  The new intervention has low COVID-19 risk as it was designed to be done remotely in patients' homes, using internet resources monitored by study staff.  Success in the initial 2-year research phase will prompt 3 additional years of funding to replicate any brain target engagement results, with the hope that overall project success will support a future large-scale, multi-site clinical efficacy trial.  Since 2004, Dr. Stevens has received over $10 million in research funding from the NIMH and from Harford HealthCare internal research resources specifically for ADHD translational research.  This current NIMH grant supports his latest project in a decades-long effort to use neuroimaging research tools to better understand brain dysfunction in ADHD and to learn how to best treat the disorder.  The new clinical trial plans to begin recruiting patients by mid-Spring 2021.  Information on this study will soon be available on Dr. Stevens' Olin Center lab webpage at https://instituteofliving.org/health-professionals/olin-neuropsychiatry-research-center/research/cnd-lab alongside information about other ongoing ADHD-focused projects that are actively recruiting ADHD and non-ADHD research participants.

Recent Publications

September, 2021

Asempa TE,DeRosa NA,Cassino C,Lehoux D,Schuch R,Nicolau DP Efficacy assessment of lysin CF-296 in addition to daptomycin or vancomycin against Staphylococcus aureus in the murine thigh infection model. The Journal of antimicrobial chemotherapy

Chapman BP,Lai JT,Krotulski AJ,Fogarty MF,Griswold MK,Logan BK,Babu KM A Case of Unintentional Opioid (U-47700) Overdose in a Young Adult After Counterfeit Xanax Use. Pediatric emergency care

Corbera S,Wexler BE,Bell MD,Pearlson G,Mayer S,Pittman B,Belamkar V,Assaf M Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder. Psychiatry research

Costa OS,O'Donnell B,Vardar B,Abdelgawwad K,Brescia CW,Sood N,Coleman CI Kidney, limb and ophthalmic complications, and death in patients with nonvalvular atrial fibrillation and type 2 diabetes prescribed rivaroxaban or warfarin: an electronic health record analysis. Current medical research and opinion

D'Amico AV,Xie W,McMahon E,Loffredo M,Medeiros S,Joseph D,Denham J,Kumar P,Bubley G,Sullivan M,Hellwig R,Carlos Vera J,Freter R,Jeffrey Baker W,Wong JY,Renshaw AA,Kantoff PW Radiation and Androgen Deprivation Therapy With or Without Docetaxel in the Management of Nonmetastatic Unfavorable-Risk Prostate Cancer: A Prospective Randomized Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Errthum R,Caballero A,McKay R,Sun W Comparative computational analysis of PASCAL and MitraClip implantation in a patient-specific functional mitral regurgitation model. Computers in biology and medicine

Eum S,Hill SK,Alliey-Rodriguez N,Stevenson JM,Rubin LH,Lee AM,Mills LJ,Reilly JL,Lencer R,Keedy SK,Ivleva E,Keefe RSE,Pearlson GD,Clementz BA,Tamminga CA,Keshavan MS,Gershon ES,Sweeney JA,Bishop JR Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Feduraev P,Riabova A,Skrypnik L,Pungin A,Tokupova E,Maslennikov P,Chupakhina G Assessment of the Role of PAL in Lignin Accumulation in Wheat (Triticum aestivum L.) at the Early Stage of Ontogenesis. International journal of molecular sciences

Firmin RL,Zalzala AB,Hamm JA,Luther L,Lysaker PH How psychosis interrupts the lives of women and men differently: a qualitative comparison. Psychology and psychotherapy

Fratoni AJ,Kuti JL,Nicolau DP Optimised cefiderocol exposures in a successfully treated critically ill patient with polymicrobial Stenotrophomonas maltophilia bacteraemia and pneumonia receiving continuous venovenous haemodiafiltration. International journal of antimicrobial agents

Gill CM,Abdelraouf K,Oota M,Nakamura R,Kuroiwa M,Gahara Y,Takemura M,Yamano Y,Nicolau DP Discrepancy in sustained efficacy and resistance emergence under human-simulated exposure of cefiderocol against Stenotrophomonas maltophilia between in vitro chemostat and in vivo murine infection models. The Journal of antimicrobial chemotherapy

Gill CM,Kresken M,Seifert H,Nicolau DP Evaluation of a Phenotypic Algorithm to Direct Carbapenemase Testing in Pseudomonas aeruginosa: Validation in a Multicenter German Cohort. Microbial drug resistance (Larchmont, N.Y.)

Hunter AA,DiVietro S,Boyer M,Burnham K,Chenard D,Rogers SC The practice of lethal means restriction counseling in US emergency departments to reduce suicide risk: a systematic review of the literature. Injury epidemiology

Jaiswal A,Gadela NV,Baran D,Balakumaran K,Scatola A,Radojevic J,Gluck J,Arora S,Hammond J,Ali A,Jennings DL,Baker WL Clinical outcomes of older adults listed for heart transplantation in the United States. Journal of the American Geriatrics Society

Knowles EEM,Peralta JM,Almasy L,Nimgaonkar V,McMahon FJ,McIntosh AM,Thomson P,Mathias SR,Gur RC,Curran JE,Raventos H,Contreras J,Jablensky A,Badcock J,Blangero J,Gur RE,Glahn DC Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex Pedigrees. Biological psychiatry

Lam M,Chen CY,Ge T,Xia Y,Hill DW,Trampush JW,Yu J,Knowles E,Davies G,Stahl EA,Huckins L,Liewald DC,Djurovic S,Melle I,Christoforou A,Reinvang I,DeRosse P,Lundervold AJ,Steen VM,Espeseth T,Raikkonen K,Widen E,Palotie A,Eriksson JG,Giegling I,Konte B,Hartmann AM,Roussos P,Giakoumaki S,Burdick KE,Payton A,Ollier W,Chiba-Falek O,Koltai DC,Need AC,Cirulli ET,Voineskos AN,Stefanis NC,Avramopoulos D,Hatzimanolis A,Smyrnis N,Bilder RM,Freimer NB,Cannon TD,London E,Poldrack RA,Sabb FW,Congdon E,Conley ED,Scult MA,Dickinson D,Straub RE,Donohoe G,Morris D,Corvin A,Gill M,Hariri AR,Weinberger DR,Pendleton N,Bitsios P,Rujescu D,Lahti J,Le Hellard S,Keller MC,Andreassen OA,Deary IJ,Glahn DC,Huang H,Liu C,Malhotra AK,Lencz T Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Mokha JS,Hyams JS,Glidden NC,Balarezo F,Young E Characterizing clinical features and location-specific gene expression profiles associated with pain burden in children with functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Peterson AT,Bakaysa SL,Driscoll JM,Kalyanaraman R,House MD Randomized controlled trial of single-use negative-pressure wound therapy dressings in morbidly obese patients undergoing cesarean delivery. American journal of obstetrics & gynecology MFM

Schwab-Reese LM,Murfree L,Coppola EC,Liu PJ,Hunter AA Homicide-suicide across the lifespan: a mixed methods examination of factors contributing to older adult perpetration. Aging & mental health

Skrypnik L,Maslennikov P,Feduraev P,Pungin A,Belov N Changes in Antioxidative Compounds and Enzymes in Small-Leaved Linden (Tilia cordata Mill.) in Response to Mistletoe (Viscum album L.) Infestation. Plants (Basel, Switzerland)

Smarz K,Jaxa-Chamiec T,Zaborska B,Tysarowski M,Budaj A Mechanisms of Exercise Capacity Improvement after Cardiac Rehabilitation Following Myocardial Infarction Assessed with Combined Stress Echocardiography and Cardiopulmonary Exercise Testing. Journal of clinical medicine

Valdes-Fernandez BN,Duconge J,Espino AM,Ruano G Personalized health and the coronavirus vaccines-Do individual genetics matter? BioEssays : news and reviews in molecular, cellular and developmental biology

Wakefield EO,Mathew ES,Zempsky WT Supporting the Imperfect Use of Amplified Pain Syndrome. JAMA pediatrics

Wootton BM,Bragdon LB,Worden BL,Diefenbach GJ,Stevens MC,Tolin DF Measuring Within-Session and Between-Session Compliance in Hoarding Disorder: A Preliminary Investigation of the Psychometric Properties of the CBT Compliance Measure (CCM) and Patient Exposure/Response Prevention Adherence Scale for Hoarding (PEAS-H). Assessment