Research News

Full AAHRPP Accreditation for the Hartford HealthCare Human Research Protection Program

The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP) recently awarded the Hartford HealthCare Human Research Protection Program (HRPP) the designation of Full Accreditation for a period of five years. This is an important achievement and reflects the commitment of our organization and Institutional Review Boards to protect the rights and welfare of Hartford HealthCare research participants. The Council also recognized our program’s innovative practices with an Area of Distinction award. The award acknowledged the development and implementation of a noncompliance tracking system which allows our HRPP team to continuously monitor the frequency and type of noncompliance events. These metrics are utilized to institute targeted education and changes in practice.

Dr. Michael Stevens Receives $3.7M Grant for ADHD Research

The National Institute of Mental Health has awarded a $3.7M research grant to Dr. Michael Stevens at the Olin Neuropsychiatry Research Center to test a new computerized cognitive training intervention for teens diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD).  This two-phase, 5-year clinical trial will test whether ADHD symptom severity can be reduced following a month of near-daily cognitive training sessions.  This study is based on recent neuroscience discovery of how specific ADHD brain function abnormalities seem to be improved through a particular focus of cognitive training.  The intervention targets the way specific frontal lobe brain regions communicate with other brain regions engaged to hold and manipulate information in mind that prior research has linked to ADHD symptom expression.  The new intervention has low COVID-19 risk as it was designed to be done remotely in patients' homes, using internet resources monitored by study staff.  Success in the initial 2-year research phase will prompt 3 additional years of funding to replicate any brain target engagement results, with the hope that overall project success will support a future large-scale, multi-site clinical efficacy trial.  Since 2004, Dr. Stevens has received over $10 million in research funding from the NIMH and from Harford HealthCare internal research resources specifically for ADHD translational research.  This current NIMH grant supports his latest project in a decades-long effort to use neuroimaging research tools to better understand brain dysfunction in ADHD and to learn how to best treat the disorder.  The new clinical trial plans to begin recruiting patients by mid-Spring 2021.  Information on this study will soon be available on Dr. Stevens' Olin Center lab webpage at alongside information about other ongoing ADHD-focused projects that are actively recruiting ADHD and non-ADHD research participants.

Recent Publications

April, 2022

Ananeva A,Bakulina O,Dar'in D,Kantin G,Krasavin M Dicarboxylic Acid Monoesters in beta- and delta-Lactam Synthesis. Molecules (Basel, Switzerland)

Shuvaev AN,Belozor OS,Mozhei OI,Mileiko AG,Mosina LD,Laletina IV,Mikhailov IG,Fritsler YV,Shuvaev AN,Teschemacher AG,Kasparov S Memantine Disrupts Motor Coordination through Anxiety-like Behavior in CD1 Mice. Brain sciences

Gill CM,Fratoni AJ,Shepard AK,Kuti JL,Nicolau DP Omadacycline pharmacokinetics and soft-tissue penetration in diabetic patients with wound infections and healthy volunteers using in vivo microdialysis. The Journal of antimicrobial chemotherapy

Labib A,August E,Agerstrand C,Frenckner B,Laufenberg D,Lavandosky G,Fajardo C,Gluck JA,Brodie D Extracorporeal Life Support Organization Guideline for Transport and Retrieval of Adult and Pediatric Patients with ECMO Support. ASAIO journal (American Society for Artificial Internal Organs : 1992)

DeMartini KS,Gueorguieva R,Taylor JR,Krishnan-Sarin S,Pearlson G,Krystal JH,O'Malley SS Dynamic structural equation modeling of the relationship between alcohol habit and drinking variability. Drug and alcohol dependence

Ratzan RM They Also Serve Who Only Sit and Answer COVID-19 Hotline Telephones. The Journal of emergency medicine

Abouelhassan YP,Nicolau D Pharmacokinetic/Pharmacodynamic Optimization of Hospital-Acquired and Ventilator-Associated Pneumonia: Challenges and Strategies. Seminars in respiratory and critical care medicine

Angiolillo DJ,Prats J,Deliargyris EN,Schneider DJ,Scheiman J,Kimmelstiel C,Steg PG,Alberts M,Rosengart T,Mehran R,Bhatt DL Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation. Clinical pharmacokinetics

Han P,Wu S,Li L,Li D,Zhao J,Zhang H,Wang Y,Zhong X,Zhang Z,Li P,Matskova L,Zhou X Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma. Genes & genomics

Patel P,Thompson PD Diagnosing COVID-19 myocarditis in athletes using cMRI. Trends in cardiovascular medicine

Geiselmann MT,Goldberg LK,Strecker SE,Witmer DK Does the Use of an Intra-Articular Local Anesthetic Injection During Total Hip Arthroplasty Reduce Patient Reported Pain Scores or Patient Opioid Consumption? The Journal of arthroplasty

Yang D,King W,Aihara H,Karasik MS,Ngamruengphong S,Aadam AA,Othman MO,Sharma N,Grimm IS,Rostom A,Elmunzer BJ,Jawaid SA,Perbtani YB,Hoffman BJ,Akki AS,Schlachterman A,Coman RM,Wang AY,Draganov PV Effect of endoscopic submucosal dissection on histologic diagnosis in Barrett's esophagus visible neoplasia. Gastrointestinal endoscopy

Wang R,Tunitsky-Bitton E,Ramaseshan AS Hysterectomy Versus Uterine Preservation at the Time of Pelvic Reconstructive Surgery. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Smith KW,Sicignano DJ,Hernandez AV,White CM MDMA-Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta-Analysis. Journal of clinical pharmacology

Hart A,Romney D,Sarin R,Mechanic O,Hertelendy AJ,Larson D,Rhone K,Sidel K,Voskanyan A,Ciottone GR Developing Telemedicine Curriculum Competencies for Graduate Medical Education: Outcomes of a Modified Delphi Process. Academic medicine : journal of the Association of American Medical Colleges

Ali A,Mather JF,McMahon S,Curtis LE,Hoover N,Ayer C,Amer MR,Dibble T,Roper L,Orlando R,McKay RG Racial and Ethnic Disparities in the Use of Transcatheter Aortic Valve Replacement in the State of Connecticut. Cardiovascular revascularization medicine : including molecular interventions

Diefenbach GJ,Stevens KT,Dunlap A,Nicholson AM,Grella ON,Pearlson G,Assaf M Autistic Traits Moderate Reappraisal Success for Depression and Anxiety Symptoms. Journal of autism and developmental disorders

Henzlova MJ,Duvall L Is the CZT technology the future of nuclear cardiology? Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Finitsis DJ,Cruess DG,Pinnamaraju S,Robinson P,Woodruff TA Brief, peer-delivered motivational interview promotes help seeking behavior among college students with needle anxiety: A randomized controlled trial. Journal of American college health : J of ACH

March, 2022

Althoff A,Papasavas P,Olugbile S,Wu U,Roberts AL,O'Sullivan DM,McLaughlin T,Mather JF,Steinberg AC,Orlando R,Kumar A Factors affecting seroreversion by 6 months among healthcare workers in Connecticut. The Journal of hospital infection

Babich O,Larina V,Ivanova S,Tarasov A,Povydysh M,Orlova A,Strugar J,Sukhikh S Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity. Molecules (Basel, Switzerland)

Babich O,Sukhikh S,Larina V,Kalashnikova O,Kashirskikh E,Prosekov A,Noskova S,Ivanova S,Fendri I,Smaoui S,Abdelkafi S,Michaud P,Dolganyuk V Algae: Study of Edible and Biologically Active Fractions, Their Properties and Applications. Plants (Basel, Switzerland)

Chaudhary AMD,Naveed S,Saboor S,Safdar B,Azeem MW,Khosa F Gender and Racial Disparities among US Psychiatry Residents: A Review of Trends. The Psychiatric quarterly

Dave AD,Ruano G,Kost J,Wang X Automated Extraction of Pain Symptoms: A Natural Language Approach using Electronic Health Records. Pain physician

Fratoni AJ,Nicolau DP,Kuti JL Minocycline pharmacodynamics against Stenotrophomonas maltophilia in the neutropenic murine infection model: implications for susceptibility breakpoints. The Journal of antimicrobial chemotherapy

Green AK,Tabatabai SM,Bai X,Mishra Meza A,Lesny AM,Aghajanian C,Landgren O,Riely GJ,Sabbatini P,Salner A,Lipkin S,Ip A,Bach PB,Begg CB,Mailankody S,Lipitz-Snyderman A Validation of a Population-Based Data Source to Examine National Cancer Clinical Trial Participation. JAMA network open

Grella ON,Dunlap A,Nicholson AM,Stevens K,Pittman B,Corbera S,Diefenbach G,Pearlson G,Assaf M Personality as a mediator of autistic traits and internalizing symptoms in two community samples. BMC psychology

Hafeez S,Mnayer LO,DiGiuseppe JA CD4+ T-cell large granular lymphocytic leukemia with STAT3 mutation and neutropenia. Cytometry. Part B, Clinical cytometry

Houston LJ,DeJong SM,Brenner AM,Macaluso M,Kinzie JM,Arbuckle MR,Janssen F,Cowley DS,Bentman AL Challenges of Assessing Resident Competency in Well-Being: Development of the Psychiatry Milestones 2.0 Well-Being Subcompetency. Academic medicine : journal of the Association of American Medical Colleges

Hunter AA,Schwab-Reese L,DiVietro S,McCollum S An examination of fatal child poisonings in the United States using the National Violent Death Reporting System (NVDRS), 2012-2017. Clinical toxicology (Philadelphia, Pa.)

Kia C,Antonacci CL,Wellington I,Makanji HS,Esmende SM Spinal Implant Osseointegration and the Role of 3D Printing: An Analysis and Review of the Literature. Bioengineering (Basel, Switzerland)

Lasko MJ,Serrano OK,Kois AK,Nicolau DP,Kuti JL Effect of Blood Product Resuscitation on the Pharmacokinetics of Ampicillin-Sulbactam during Orthotopic Liver Transplantation. Surgical infections

LeVasseur MR,Cusano A,Mancini MR,Uyeki CL,Pina MJ,Obopilwe E,Caputo AE,Mazzocca AD Augmentation of Distal Biceps Tendon Ruptures With the Lacertus Fibrosus: A Biomechanical Study in a Tendon-Deficient Model. The American journal of sports medicine

Levy HC,Stevens KT,Tolin DF Research Review: A meta-analysis of relapse rates in cognitive behavioral therapy for anxiety and related disorders in youth. Journal of child psychology and psychiatry, and allied disciplines

Panza GA,Steere L,Steinberg AC A New Force-Activated Separation Device for the Prevention of Peripheral Intravenous Restarts. Journal of infusion nursing : the official publication of the Infusion Nurses Society

Patel KT,Stevens MC,Dunlap A,Gallagher A,O'Malley SS,DeMartini K,Potenza MN,Krystal JH,Pearlson GD Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Ratzan RM Retirement: While My Stethoscope Gently Weeps (With Apologies to George Harrison). The Journal of emergency medicine

Sharma MS,De Maio M,Young K,Santopietro J Transformation of Outpatient Psychiatry. The Psychiatric clinics of North America

Sukhera J,Ahmed H Leveraging Machine Learning to Understand How Emotions Influence Equity Related Education: Quasi-Experimental Study. JMIR medical education

Thompson PD The Role of Physical Activity and Exercise in Preventive Cardiology. The Medical clinics of North America

Wang R,Harvie HS Is Delaying Urogynecologic Surgery for Patients With Elevated Hemoglobin A1C High-Value Care? Female pelvic medicine & reconstructive surgery

White CM,White LR Preventing a New Tuskegee: Food and Drug Administration Oversight of Overseas Research Must Match That in the United States. Journal of clinical pharmacology

Witmer D,Solomito MJ,Kumar M,Shearier E,Davis S Efficacy and Safety of Locally Injected Tranexamic Acid in Hip Fracture Patients: A Retrospective Review. Journal of orthopaedic trauma

Yaghi S,Shu L,Bakradze E,Salehi Omran S,Giles JA,Amar JY,Henninger N,Elnazeir M,Liberman AL,Moncrieffe K,Lu J,Sharma R,Cheng Y,Zubair AS,Simpkins AN,Li GT,Kung JC,Perez D,Heldner M,Scutelnic A,Seiffge D,Siepen B,Rothstein A,Khazaal O,Do D,Kasab SA,Rahman LA,Mistry EA,Kerrigan D,Lafever H,Nguyen TN,Klein P,Aparicio H,Frontera J,Kuohn L,Agarwal S,Stretz C,Kala N,El Jamal S,Chang A,Cutting S,Xiao H,de Havenon A,Muddasani V,Wu T,Wilson D,Nouh A,Asad SD,Qureshi A,Moore J,Khatri P,Aziz Y,Casteigne B,Khan M,Cheng Y,Mac Grory B,Weiss M,Ryan D,Vedovati MC,Paciaroni M,Siegler JE,Kamen S,Yu S,Leon Guerrero CR,Atallah E,De Marchis GM,Brehm A,Dittrich T,Psychogios M,Alvarado-Dyer R,Kass-Hout T,Prabhakaran S,Honda T,Liebeskind DS,Furie K Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study. Stroke