Research News

Full AAHRPP Accreditation for the Hartford HealthCare Human Research Protection Program

The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP) recently awarded the Hartford HealthCare Human Research Protection Program (HRPP) the designation of Full Accreditation for a period of five years. This is an important achievement and reflects the commitment of our organization and Institutional Review Boards to protect the rights and welfare of Hartford HealthCare research participants. The Council also recognized our program’s innovative practices with an Area of Distinction award. The award acknowledged the development and implementation of a noncompliance tracking system which allows our HRPP team to continuously monitor the frequency and type of noncompliance events. These metrics are utilized to institute targeted education and changes in practice.


Dr. Michael Stevens Receives $3.7M Grant for ADHD Research

The National Institute of Mental Health has awarded a $3.7M research grant to Dr. Michael Stevens at the Olin Neuropsychiatry Research Center to test a new computerized cognitive training intervention for teens diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD).  This two-phase, 5-year clinical trial will test whether ADHD symptom severity can be reduced following a month of near-daily cognitive training sessions.  This study is based on recent neuroscience discovery of how specific ADHD brain function abnormalities seem to be improved through a particular focus of cognitive training.  The intervention targets the way specific frontal lobe brain regions communicate with other brain regions engaged to hold and manipulate information in mind that prior research has linked to ADHD symptom expression.  The new intervention has low COVID-19 risk as it was designed to be done remotely in patients' homes, using internet resources monitored by study staff.  Success in the initial 2-year research phase will prompt 3 additional years of funding to replicate any brain target engagement results, with the hope that overall project success will support a future large-scale, multi-site clinical efficacy trial.  Since 2004, Dr. Stevens has received over $10 million in research funding from the NIMH and from Harford HealthCare internal research resources specifically for ADHD translational research.  This current NIMH grant supports his latest project in a decades-long effort to use neuroimaging research tools to better understand brain dysfunction in ADHD and to learn how to best treat the disorder.  The new clinical trial plans to begin recruiting patients by mid-Spring 2021.  Information on this study will soon be available on Dr. Stevens' Olin Center lab webpage at https://instituteofliving.org/health-professionals/olin-neuropsychiatry-research-center/research/cnd-lab alongside information about other ongoing ADHD-focused projects that are actively recruiting ADHD and non-ADHD research participants.


Recent Publications

October, 2022

Acute Care Surgery

Levy MJ,Krohmer J,Goralnick E,Charlton N,Nemeth I,Jacobs L,Goolsby CA A framework for the design and implementation of Stop the Bleed and public access trauma equipment programs. Journal of the American College of Emergency Physicians

Jacobs L,Keating JJ,Hunt RC,Butler FK,Pons PT,Gestring M,Bulger E,Eastman A,Kerby J,Hashmi Z,Fridling J,Inaba K,Matsushima K,Goralnick E,Melnitchouk N,Welten V Stop the Bleed(). Current problems in surgery

Kennedy GT,Azari FS,Chang A,Nadeem B,Bernstein E,Segil A,Din A,Marfatia I,Desphande C,Okusanya O,Keating J,Predina J,Newton A,Kucharczuk JC,Singhal S Comparative Experience of Short-wavelength Versus Long-wavelength Fluorophores for Intraoperative Molecular Imaging of Lung Cancer. Annals of surgery

Anesthesiology

Finkel KJ,Takata ET,Maffeo-Mitchell CL,Neal JB,Nankin MD,Braffett BH,Perillo LM,Gammerman S,Stuart WT,Walker A Manufacturer financial conflicts of interest are associated with favourable outcomes in randomised controlled trials of liposomal bupivacaine. British journal of anaesthesia

Cardiology

Miller EJ,Campisi R,Shah NR,McMahon S,Cuddy S,Gallegos-Kattan C,Maurer MS,Damy T,Slart RHJA,Bhatia K,Einstein AJ Radiopharmaceutical supply disruptions and the use of (99m)Tc-hydroxymethylene diphosphonate as an alternative to (99m)Tc-pyrophosphate for the diagnosis of transthyretin cardiac amyloidosis: An ASNC Information Statement. Journal of nuclear cardiology: official publication of the American Society of Nuclear Cardiology

Center for AntiInfective Research and Development

Kobic E,Abouelhassan Y,Singaravelu K,Nicolau DP Pharmacokinetic Analysis and In Vitro Synergy Evaluation of Cefiderocol, Sulbactam, and Tigecycline in an Extensively Drug-Resistant Acinetobacter baumannii Pneumonia Patient Receiving Continuous Venovenous Hemodiafiltration. Open forum infectious diseases

Lasko MJ,Tabor-Rennie JL,Nicolau DP,Kuti JL Trimethoprim/sulfamethoxazole pharmacodynamics against Stenotrophomonas maltophilia in the in vitro chemostat model. The Journal of antimicrobial chemotherapy

Fratoni AJ,Mah JW,Nicolau DP,Kuti JL Imipenem/cilastatin/relebactam pharmacokinetics in critically ill patients with augmented renal clearance. The Journal of antimicrobial chemotherapy

Emergency Medicine

Gohde E,Irfanullah I,Bolton L,Osumah N,Herbst T,Stroh DA,Herbst MK Elderly Woman With Left Shoulder Pain After a Fall. Annals of emergency medicine

Medicine

Parikh R,Konstantinidis I,O'Sullivan DM,Farber HW Pulmonary hypertension in patients with interstitial lung disease: a tool for early detection. Pulmonary circulation

Neurology

Grosberg B,Rabany L,Vizel M,Ironi A,Harris D,Stark-Inbar A,Smith TR Effectiveness comparison of remote electrical neuromodulation and standard-care medications for acute treatment of chronic migraine: a post-hoc analysis. Pain management

Finelli PF Biopsy negative giant cell arteritis-Revised diagnostic criteria: Giant cell arteritis diagnostic criteria. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association

Orthopedics/Anesthesiology

Esmende SM,Solomito MJ,Eisler J,Finkel KJ,Kainkaryam PP,Maffeo-Mitchell CL Utility of the transversus abdominis plane and rectus sheath blocks in patients undergoing anterior lumbar interbody fusions. The spine journal: official journal of the North American Spine Society

Psychiatry

Davis BJ,Bonfils KA,Zalzala A,Lysaker PH,Minor KS Meaning-making processes across the lifespan: An investigation of the developmental course of metacognitive capacity. Schizophrenia research

Liu LX,Goldszmidt M,Calvert S,Burm S,Torti J,Cristancho S,Sukhera J From distress to detachment: exploring how providing care for stigmatized patients influences the moral development of medical trainees. Advances in health sciences education: theory and practice

Surgery

Raftopoulos Y,Rajkumar S,Davidson E,Papasavas P Prospective Randomized Comparison of Linear Endostaplers During Laparoscopic Sleeve Gastrectomy. Obesity surgery

Urso B,Kelsey A,Bordelon J,Sheiner P,Finch J,Cohen JL Risk factors and prevention strategies for cutaneous squamous cell carcinoma in transplant recipients. International journal of dermatology

Urogynecology

Sindvani R,Isakoff M,Tunitsky-Bitton E Pelvic Lymphovascular Malformation Presenting as a Vulvar Mass in an Adolescent Female. Journal of pediatric and adolescent gynecology


Annual Publications, 2022

Koenis MMG,Ng J,Anderson B,Stevens MC,Tishler DS,Papasavas PK,Stone A,McLaughlin T,Verhaak A,Domakonda MJ,Pearlson GD Food cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study. Frontiers in human neuroscience

Young KP,Kolcz DL,Ferrand J,O'Sullivan DM,Robinson K Healthcare Worker Mental Health and Wellbeing During COVID-19: Mid-Pandemic Survey Results. Frontiers in psychology

Banach M,Shekoohi N,Mikhailidis DP,Lip GYH,Hernandez AV,Mazidi M Relationship between low-density lipoprotein cholesterol, lipid-lowering agents and risk of stroke: a meta-analysis of observational studies (n = 355,591) and randomized controlled trials (n = 165,988). Archives of medical science : AMS

Luo C,Chen K,Doshi R,Rickles N,Chen Y,Schwartz H,Aseltine RH The association of prescription opioid use with suicide attempts: An analysis of statewide medical claims data. PloS one

DeRamus TP,Wu L,Qi S,Iraji A,Silva R,Du Y,Pearlson G,Mayer A,Bustillo JR,Stromberg SF,Calhoun VD Multimodal data fusion of cortical-subcortical morphology and functional network connectivity in psychotic spectrum disorder. NeuroImage. Clinical

Hou Y,Elmashad A,Staff I,Alberts M,Nouh A Potential Embolic Sources Differ in Patients With Embolic Stroke of Undetermined Source According to Age: A 15-Year Study. Frontiers in neurology

Ouyang X,Chen Y,Tejaswi BS,Arumugam S,Secor E,Weiss TR,Leapman M,Ali A Fermented Soy Drink (Q-CAN(R) PLUS) Induces Apoptosis and Reduces Viability of Cancer Cells. Nutrition and cancer

Kilbourn KJ,Green J,Zacharewski N,Aferzon J,Lawlor M,Jaffa M Intracranial fungal Cladophialophora bantiana infection in a nonimmunocompromised patient: A case report and review of the literature. Surgical neurology international

Berry AV,Kuti JL Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man. Frontiers in pharmacology

Tailor N,Dean MR,Dellalana M,Jitendranath L Gonococcal endocarditis with aortic root abscess and severe aortic insufficiency. IDCases

Panjwani S,Walker D,Gates J,Katigbak M,Ricaurte D Lung herniation following a severe traumatic chest wall injury. Trauma surgery & acute care open

Alnoaimi MM,Hart A,Issa F,Hertelendy A,Voskanyan A,Ciottone G Variance Analysis of Expatriate Pre-Hospital Provider Training in Bahrain. Open access emergency medicine : OAEM

Leopold SR,Abdelraouf K,Nicolau DP,Agresta H,Johnson J,Teter K,Dunne WM,Broadwell D,van Belkum A,Schechter LM,Sodergren EJ,Weinstock GM Murine Model for Measuring Effects of Humanized-Dosing of Antibiotics on the Gut Microbiome. Frontiers in microbiology

Johnstone S,Sorkhou M,Al-Saghir N,Lowe DJE,Steele VR,Pearlson GD,Castle DJ,George TP Neuromodulation to Treat Substance Use Disorders in People With Schizophrenia and Other Psychoses: A Systematic Review. Frontiers in psychiatry

Herrera-Anazco P,Benites-Zapata VA,Hernandez V Association between the Non-use of Health Services and Maltreatment Based on Ethnicity in Peru. Journal of health care for the poor and underserved

Heng JS,Kim JM,Jones DK,Stoessel KM,Weiss SA,Sznol M,Kluger HM,Walter SD,Silverstein NA,Pointdujour-Lim R Autoimmune retinopathy with associated anti-retinal antibodies as a potential immune-related adverse event associated with immunotherapy in patients with advanced cutaneous melanoma: case series and systematic review. BMJ open ophthalmology

Basheer A,Rasool M,Amin H,Saucier S Acute aortic dissection in the Marfan syndrome during the COVID-19 epidemic. Proceedings (Baylor University. Medical Center)

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