Research News

Full AAHRPP Accreditation for the Hartford HealthCare Human Research Protection Program

The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP) recently awarded the Hartford HealthCare Human Research Protection Program (HRPP) the designation of Full Accreditation for a period of five years. This is an important achievement and reflects the commitment of our organization and Institutional Review Boards to protect the rights and welfare of Hartford HealthCare research participants. The Council also recognized our program’s innovative practices with an Area of Distinction award. The award acknowledged the development and implementation of a noncompliance tracking system which allows our HRPP team to continuously monitor the frequency and type of noncompliance events. These metrics are utilized to institute targeted education and changes in practice.

Dr. Michael Stevens Receives $3.7M Grant for ADHD Research

The National Institute of Mental Health has awarded a $3.7M research grant to Dr. Michael Stevens at the Olin Neuropsychiatry Research Center to test a new computerized cognitive training intervention for teens diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD).  This two-phase, 5-year clinical trial will test whether ADHD symptom severity can be reduced following a month of near-daily cognitive training sessions.  This study is based on recent neuroscience discovery of how specific ADHD brain function abnormalities seem to be improved through a particular focus of cognitive training.  The intervention targets the way specific frontal lobe brain regions communicate with other brain regions engaged to hold and manipulate information in mind that prior research has linked to ADHD symptom expression.  The new intervention has low COVID-19 risk as it was designed to be done remotely in patients' homes, using internet resources monitored by study staff.  Success in the initial 2-year research phase will prompt 3 additional years of funding to replicate any brain target engagement results, with the hope that overall project success will support a future large-scale, multi-site clinical efficacy trial.  Since 2004, Dr. Stevens has received over $10 million in research funding from the NIMH and from Harford HealthCare internal research resources specifically for ADHD translational research.  This current NIMH grant supports his latest project in a decades-long effort to use neuroimaging research tools to better understand brain dysfunction in ADHD and to learn how to best treat the disorder.  The new clinical trial plans to begin recruiting patients by mid-Spring 2021.  Information on this study will soon be available on Dr. Stevens' Olin Center lab webpage at alongside information about other ongoing ADHD-focused projects that are actively recruiting ADHD and non-ADHD research participants.

Recent Publications

May, 2022

Lalla RV,Treister NS,Sollecito TP,Schmidt BL,Patton LL,Helgeson ES,Lin A,Rybczyk C,Dowsett R,Hegde U,Boyd TS,Duplinsky TG,Brennan MT Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries. Oral surgery, oral medicine, oral pathology and oral radiology

Cipriani NA,Glomski K,Sadow PM Intraoperative assessment of parathyroid pathology in sporadic primary hyperparathyroidism: an institutional experience. Human pathology

Kawaguchi N,Katsube T,Echols R,Wajima T,Nicolau DP Intrapulmonary Pharmacokinetic Modeling and Simulation of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Patients With Pneumonia and Healthy Subjects. Journal of clinical pharmacology

April, 2022

Ananeva A,Bakulina O,Dar'in D,Kantin G,Krasavin M Dicarboxylic Acid Monoesters in beta- and delta-Lactam Synthesis. Molecules (Basel, Switzerland)

Shuvaev AN,Belozor OS,Mozhei OI,Mileiko AG,Mosina LD,Laletina IV,Mikhailov IG,Fritsler YV,Shuvaev AN,Teschemacher AG,Kasparov S Memantine Disrupts Motor Coordination through Anxiety-like Behavior in CD1 Mice. Brain sciences

Gill CM,Fratoni AJ,Shepard AK,Kuti JL,Nicolau DP Omadacycline pharmacokinetics and soft-tissue penetration in diabetic patients with wound infections and healthy volunteers using in vivo microdialysis. The Journal of antimicrobial chemotherapy

Labib A,August E,Agerstrand C,Frenckner B,Laufenberg D,Lavandosky G,Fajardo C,Gluck JA,Brodie D Extracorporeal Life Support Organization Guideline for Transport and Retrieval of Adult and Pediatric Patients with ECMO Support. ASAIO journal (American Society for Artificial Internal Organs : 1992)

DeMartini KS,Gueorguieva R,Taylor JR,Krishnan-Sarin S,Pearlson G,Krystal JH,O'Malley SS Dynamic structural equation modeling of the relationship between alcohol habit and drinking variability. Drug and alcohol dependence

Ratzan RM They Also Serve Who Only Sit and Answer COVID-19 Hotline Telephones. The Journal of emergency medicine

Abouelhassan YP,Nicolau D Pharmacokinetic/Pharmacodynamic Optimization of Hospital-Acquired and Ventilator-Associated Pneumonia: Challenges and Strategies. Seminars in respiratory and critical care medicine

Angiolillo DJ,Prats J,Deliargyris EN,Schneider DJ,Scheiman J,Kimmelstiel C,Steg PG,Alberts M,Rosengart T,Mehran R,Bhatt DL Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation. Clinical pharmacokinetics

Han P,Wu S,Li L,Li D,Zhao J,Zhang H,Wang Y,Zhong X,Zhang Z,Li P,Matskova L,Zhou X Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma. Genes & genomics

Patel P,Thompson PD Diagnosing COVID-19 myocarditis in athletes using cMRI. Trends in cardiovascular medicine

Geiselmann MT,Goldberg LK,Strecker SE,Witmer DK Does the Use of an Intra-Articular Local Anesthetic Injection During Total Hip Arthroplasty Reduce Patient Reported Pain Scores or Patient Opioid Consumption? The Journal of arthroplasty

Yang D,King W,Aihara H,Karasik MS,Ngamruengphong S,Aadam AA,Othman MO,Sharma N,Grimm IS,Rostom A,Elmunzer BJ,Jawaid SA,Perbtani YB,Hoffman BJ,Akki AS,Schlachterman A,Coman RM,Wang AY,Draganov PV Effect of endoscopic submucosal dissection on histologic diagnosis in Barrett's esophagus visible neoplasia. Gastrointestinal endoscopy

Wang R,Tunitsky-Bitton E,Ramaseshan AS Hysterectomy Versus Uterine Preservation at the Time of Pelvic Reconstructive Surgery. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Smith KW,Sicignano DJ,Hernandez AV,White CM MDMA-Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta-Analysis. Journal of clinical pharmacology

Hart A,Romney D,Sarin R,Mechanic O,Hertelendy AJ,Larson D,Rhone K,Sidel K,Voskanyan A,Ciottone GR Developing Telemedicine Curriculum Competencies for Graduate Medical Education: Outcomes of a Modified Delphi Process. Academic medicine : journal of the Association of American Medical Colleges

Ali A,Mather JF,McMahon S,Curtis LE,Hoover N,Ayer C,Amer MR,Dibble T,Roper L,Orlando R,McKay RG Racial and Ethnic Disparities in the Use of Transcatheter Aortic Valve Replacement in the State of Connecticut. Cardiovascular revascularization medicine : including molecular interventions

Diefenbach GJ,Stevens KT,Dunlap A,Nicholson AM,Grella ON,Pearlson G,Assaf M Autistic Traits Moderate Reappraisal Success for Depression and Anxiety Symptoms. Journal of autism and developmental disorders

Henzlova MJ,Duvall L Is the CZT technology the future of nuclear cardiology? Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Finitsis DJ,Cruess DG,Pinnamaraju S,Robinson P,Woodruff TA Brief, peer-delivered motivational interview promotes help seeking behavior among college students with needle anxiety: A randomized controlled trial. Journal of American college health : J of ACH

Annual/Quarterly 2022

Berry AV,Kuti JL Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man. Frontiers in pharmacology

Tailor N,Dean MR,Dellalana M,Jitendranath L Gonococcal endocarditis with aortic root abscess and severe aortic insufficiency. IDCases

Panjwani S,Walker D,Gates J,Katigbak M,Ricaurte D Lung herniation following a severe traumatic chest wall injury. Trauma surgery & acute care open

Alnoaimi MM,Hart A,Issa F,Hertelendy A,Voskanyan A,Ciottone G Variance Analysis of Expatriate Pre-Hospital Provider Training in Bahrain. Open access emergency medicine : OAEM

Leopold SR,Abdelraouf K,Nicolau DP,Agresta H,Johnson J,Teter K,Dunne WM,Broadwell D,van Belkum A,Schechter LM,Sodergren EJ,Weinstock GM Murine Model for Measuring Effects of Humanized-Dosing of Antibiotics on the Gut Microbiome. Frontiers in microbiology

Johnstone S,Sorkhou M,Al-Saghir N,Lowe DJE,Steele VR,Pearlson GD,Castle DJ,George TP Neuromodulation to Treat Substance Use Disorders in People With Schizophrenia and Other Psychoses: A Systematic Review. Frontiers in psychiatry

Herrera-Anazco P,Benites-Zapata VA,Hernandez V Association between the Non-use of Health Services and Maltreatment Based on Ethnicity in Peru. Journal of health care for the poor and underserved

Heng JS,Kim JM,Jones DK,Stoessel KM,Weiss SA,Sznol M,Kluger HM,Walter SD,Silverstein NA,Pointdujour-Lim R Autoimmune retinopathy with associated anti-retinal antibodies as a potential immune-related adverse event associated with immunotherapy in patients with advanced cutaneous melanoma: case series and systematic review. BMJ open ophthalmology

Basheer A,Rasool M,Amin H,Saucier S Acute aortic dissection in the Marfan syndrome during the COVID-19 epidemic. Proceedings (Baylor University. Medical Center)