Research News

Full AAHRPP Accreditation for the Hartford HealthCare Human Research Protection Program

The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP) recently awarded the Hartford HealthCare Human Research Protection Program (HRPP) the designation of Full Accreditation for a period of five years. This is an important achievement and reflects the commitment of our organization and Institutional Review Boards to protect the rights and welfare of Hartford HealthCare research participants. The Council also recognized our program’s innovative practices with an Area of Distinction award. The award acknowledged the development and implementation of a noncompliance tracking system which allows our HRPP team to continuously monitor the frequency and type of noncompliance events. These metrics are utilized to institute targeted education and changes in practice.

Dr. Michael Stevens Receives $3.7M Grant for ADHD Research

The National Institute of Mental Health has awarded a $3.7M research grant to Dr. Michael Stevens at the Olin Neuropsychiatry Research Center to test a new computerized cognitive training intervention for teens diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD).  This two-phase, 5-year clinical trial will test whether ADHD symptom severity can be reduced following a month of near-daily cognitive training sessions.  This study is based on recent neuroscience discovery of how specific ADHD brain function abnormalities seem to be improved through a particular focus of cognitive training.  The intervention targets the way specific frontal lobe brain regions communicate with other brain regions engaged to hold and manipulate information in mind that prior research has linked to ADHD symptom expression.  The new intervention has low COVID-19 risk as it was designed to be done remotely in patients' homes, using internet resources monitored by study staff.  Success in the initial 2-year research phase will prompt 3 additional years of funding to replicate any brain target engagement results, with the hope that overall project success will support a future large-scale, multi-site clinical efficacy trial.  Since 2004, Dr. Stevens has received over $10 million in research funding from the NIMH and from Harford HealthCare internal research resources specifically for ADHD translational research.  This current NIMH grant supports his latest project in a decades-long effort to use neuroimaging research tools to better understand brain dysfunction in ADHD and to learn how to best treat the disorder.  The new clinical trial plans to begin recruiting patients by mid-Spring 2021.  Information on this study will soon be available on Dr. Stevens' Olin Center lab webpage at alongside information about other ongoing ADHD-focused projects that are actively recruiting ADHD and non-ADHD research participants.

Recent Publications

May, 2021

Adams KK,Machnicz M,Sobieraj DM Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: a systematic review. Addiction science & clinical practice

Blackburn NB,Meikle PJ,Peralta JM,Kumar S,Leandro AC,Bellinger MA,Giles C,Huynh K,Mahaney MC,Goring HHH,VandeBerg JL,Williams-Blangero S,Glahn DC,Duggirala R,Blangero J,Michael LF,Curran JE Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3. Circulation. Genomic and precision medicine

Draganov PV,Aihara H,Karasik MS,Ngamruengphong S,Aadam AA,Othman MO,Sharma N,Grimm IS,Rostom A,Elmunzer BJ,Jawaid SA,Westerveld D,Perbtani YB,Hoffman BJ,Schlachterman A,Siegel A,Coman RM,Wang AY,Yang D Endoscopic Submucosal Dissection in North America: A Large Prospective Multicenter Study. Gastroenterology

Dziedzic KL,Albert RH Management of Intractable Symptoms in Oncologic Care. Current oncology reports

Gisnarian CJ,Fusco DS,Arciszewski M A Novel Approach to Identifying How Equipment Disrupts the Airflow Patterns in the Operating Room. The journal of extra-corporeal technology

Henzlova MJ,Duvall WL Did we solve soft tissue (breast) attenuation? Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Ito W,Komiyama T,Ohi T,Hiratsuka T,Matsuyama S,Sone T,Tsuji I,Watanabe M,Hattori Y Relationship Between Oral Health and Fractures in Community-Dwelling Older Japanese Adults. Journal of the American Medical Directors Association

Lambert WA,DiGiuseppe JA,Lara-Ospina T,Bookland MJ,Martin JE,Hersh DS Juvenile myelomonocytic leukemia presenting in an infant with a subdural hematoma. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Lee E,Krajewski A,Clarke C,O'Sullivan D,Herbst T,Lee S Arterial and venous thromboembolic complications of COVID-19 detected by CT angiogram and venous duplex ultrasound. Emergency radiology

Levy HC,O'Bryan EM,Tolin DF A meta-analysis of relapse rates in cognitive-behavioral therapy for anxiety disorders. Journal of anxiety disorders

Malik P,Patel U,Mehta D,Patel N,Kelkar R,Akrmah M,Gabrilove JL,Sacks H Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ evidence-based medicine

Ramsey LB,Namerow LB,Bishop JR,Hicks JK,Bousman C,Croarkin PE,Mathews CA,Van Driest SL,Strawn JR Thoughtful Clinical Use of Pharmacogenetics in Child and Adolescent Psychopharmacology. Journal of the American Academy of Child and Adolescent Psychiatry

Renner K,Queen R Detection of age and gender differences in walking using mobile wearable sensors. Gait & posture

Rocha-Santos G,Cuba GT,Cayo R,Streling AP,Nodari CS,Gales AC,Pignatari ACC,Nicolau DP,Kiffer CRV In vitro synergy of ticarcillin/clavulanate in combination with aztreonam and ceftolozane/tazobactam against SPM-1-producing Pseudomonas aeruginosa strains. Diagnostic microbiology and infectious disease

Salwan AS,Mohammedzein AIA,Alzeerah MA Incomplete Kawasaki disease with a giant coronary artery aneurysm; an unexpected finding in an adult male. International journal of cardiology. Heart & vasculature

Shah S,Nicolau DP,McManus D,Topal JE A Novel Dosing Strategy of Ceftolozane/Tazobactam in a Patient Receiving Intermittent Hemodialysis. Open forum infectious diseases

June, 2021

Armstrong JH,Jacobs LM,Jenkins DH Low-Volume, High-Risk Surgical Procedures in the Military Health System: Time for a Volume Pledge? Military medicine

Attique HB,Phachu D,Loza A,Campbell W,Hammer E,Elali I Diabetic nephropathy in pregnancy: Report of two cases progressing to end-stage renal disease within one year postpartum. Case reports in women's health

Braun TD,Gorin AA,Puhl RM,Stone A,Quinn DM,Ferrand J,Abrantes AM,Unick J,Tishler D,Papasavas P Shame and Self-compassion as Risk and Protective Mechanisms of the Internalized Weight Bias and Emotional Eating Link in Individuals Seeking Bariatric Surgery. Obesity surgery

Corradi JP,Cumarasamy CW,Staff I,Tortora J,Salner A,McLaughlin T,Wagner J Identification of a five gene signature to predict time to biochemical recurrence after radical prostatectomy. The Prostate

Dzurec L I'm Still a Nurse. Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses

Lavender Z,Collin L Thrombotic thrombocytopenic purpura. JAAPA : official journal of the American Academy of Physician Assistants

Pischel L,Geirsson A,Magaldi J,Martinello RA,Lee AI A Brewing Back Pain. The New England journal of medicine

Shuvaev AN,Belozor OS,Mozhei O,Yakovleva DA,Potapenko IV,Shuvaev AN,Smolnikova MV,Salmin VV,Salmina AB,Hirai H,Teschemacher AG,Kasparov S Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1. Neurobiology of disease

Topiwala KK,Patel SD,Pervez M,Shovlin CL,Alberts MJ Ischemic Stroke in Patients With Pulmonary Arteriovenous Fistulas. Stroke

Vaccaro AR,Fisher CG,Prasad SK,Whang PG,Dea N,Thomas KC,Mulpuri K,Makanji HS Evidence-based Recommendations for Spine Surgery. Spine