Research & Clinical Trials

The following research studies and clinical trials are being conducted by the Headache Center.

Hartford HealthCare Headache Registry

Migraine Treatment with Nerivio Migra Neurostimulation Device

Sponsor: Theranica Bioelectronics Ltd.

Status Migrainosus: Differentiating Between Responders and Non-responders in the Setup of Real-life Clinical Practice

Investigators: Dr. Rami Burstein, Beth Israel Deaconess Medical Center and Dr. Brian Grosberg, Hartford HealthCare Headache Center

Dr. Brian Grosberg, Medical Director of the Hartford HealthCare Headache Center, is co-winner of the Migraine Research Foundation's first Impact Award that will fund a 3-year study on Status Migrainosus.

To determine if you are eligible to participate in the status migrainosus study, you must first become a new patient of the Hartford HealthCare Headache Center. Click here to learn how to become a new patient.

Frequently Asked Questions

Q: What is “status migrainosus"?
Status migrainosus is a severe form of migraine that lasts for 3 or more days.

Q: What is the status migrainosus study?
The goal of the study is to explore how status migrainosus sufferers respond to different treatments and determine what treatments work best for different types of patients.

Q: If I am eligible and decide to participate, what will be my role in the study?
There will be 4 parts to the study.

  • In part 1, you will have an interview about your headaches and complete a secure, online Headache Questionnaire if you have not done so already.
  • In part 2, you will receive a treatment that the headache specialist thinks will best treat your headaches. You will know what treatment you are receiving and will be involved in making this decision. At this visit, you will also be taught how to keep a detailed headache diary.
  • In part 3, you will complete headache diaries for 30 days. The diary for the first day will be by the hour and the rest of the diaries will be daily for the next 29 days.
  • In part 4, you will have another meeting with the headache specialist. During this meeting, you will be asked to explain your headache diaries in detail so that the headache specialist can figure out whether you have responded to treatment or not.

Q: How can my participation in this study help me and other migraine sufferers?
By participating in this study, you can help take the “guess work” out of treating migraine that lasts continuously for 3 or more days. This may help to shorten and improve treatment for you and migraine sufferers worldwide.

Headache Center