Research & Clinical Trials

The following research studies and clinical trials are being conducted by the Headache Center.


Premium II Study

Principle Investigator: Dr. Abigail Chua

We are no longer recruiting for this study.

You may qualify to participate in a research study conducted at Hartford HealthCare Headache Center, of a home treatment for migraine using self-administered medical device. The study device is non-invasive and does not require taking medications. Compensation for your time and travel is available.

Frequently Asked Questions:

Q: What is the purpose of this study?
A: The purpose of this study is to evaluate the safety and effectiveness of a device called gammaCore Sapphire™ for the prevention of your migraine attacks. gammaCore Sapphire™ is a handheld, non-invasive, low voltage electrical device which stimulates the vagus nerve by producing weak 120 second electrical stimulation cycles that may help reduce, ease, lessen or stop your migraine symptoms.

Q: Am I eligible to participate?
A: To be eligible to participate in this study, you must suffer from migraines with or without Aura and be medically cleared by your doctor to take part in this study.

Q: If am eligible and choose to participate, what will be my role in the study?
A: This study is divided into two periods. The total duration of your anticipated portion, the investigation, is 4 months, including 5 clinic visits and 1 phone call.

Q: Will I be paid for taking part in this research?
A: You will not be paid to participate in this clinical trial. However, you may be reimbursed for expenses associated with the cost of travelling to your study visits. You will be paid $65.00 for in person study visit (5 in total) and $25.00 for the phone call visit (Visit 3), totalling $350.00 if you complete the entire study. This may include for example, the cost of a taxi, bus or train to and from your visits, or if you travel by car, reimbursement for your mileage. You should discuss travel reimbursement with your study doctor before enrolling in the clinical trial.

To participate, please contact the study team at 860.231.0718 or HeadacheResearch@hhchealth.org.


Neurolief Study

Principle Investigator: Dr. Brian Grosberg

We are no longer recruiting for this study.

You may qualify to participate in a research study conducted at Hartford HealthCare Headache Center, of a home treatment for migraine using self-administered investigational medical device. The study device is non-invasive and does not require medications intake. Compensation for your time and travel is available.

Frequently Asked Questions:

Q: What is the purpose of this study?
A: The Relivion™ device used in this research is an investigational external neurostimulation device, comprised of a headset with integrated electrodes. The electrodes come into contact with your scalp, and when activated, it delivers mild electrical stimulation pulses which are intended to interfere with the migraine episode. The purpose of this research is to evaluate whether the Relivion™ device is safe and helpful in alleviating migraine pain. An earlier study demonstrated positive results.

Q: Am I eligible to participate?
A: To be eligible to participate in this study, you must suffer from migraines with or without Aura and be medically cleared by your doctor to take part in this study

Q: If am eligible and choose to participate, what will be my role in the study?
A: For this study, your study doctor will schedule a minimum of 3 clinic visits with you and in between those visits, 3 periods of home diary headache reports and treatment with the device, as follows:

  • Screening visit: upon giving written consent to take part in this study, Your medical records will be reviewed by your study doctor and you will undergo a physical and neurological examination. You will be given a migraine diary, which you will be asked to fill in for the next 28 days up until your next study visit.
  • Run-In Period: For approximately 4 weeks, you will be asked to complete a Migraine Diary, you will record migraine episodes timing, duration, intensity, use of anti-pain medications and any additional symptoms such as sensitivity to noise or light and nausea.
  • Randomization visit: You will return to the clinic; the study team will review your diary to confirm you remain eligible for the study. If you are found eligible you will be trained on how to use the study device and how to report study outcomes and be released home with the device and a dedicated iPhone. You will be randomly assigned to one of 2 study groups (you cannot choose your study group; you and the study doctor will not know which group you are in):
    • Group A: active treatment at a therapeutic level.
    • Group B: sham/placebo treatment at a non-therapeutic level.
  • Self-Practice Period: In the next 2 weeks you will be asked to experience the use of the device and diary not during a migraine episode at your home or surrounding. If at least one self-practice run was successful, you will be asked to initiate the 'Treatment Period'.
  • Treatment Period: during this period, you may use the device at your home for treating a minimum 1 and up to 5 migraine episodes, for up to 10 weeks starting from the randomization visit, whichever comes first.
  • Termination visit: At the end of the Treatment Period, or after completing 5 treatments, you will return to the clinic for the last study visit. At this visit your participation in the study will be over.
    You must make sure that you can come to each visit as scheduled and perform the diary reports and device treatment at home.

Q: Will I be paid for taking part in this research?
A: For taking part in this research, you may be paid up to a total of $350. You will receive the payment after you complete the study visits.

To participate, please contact the study team at 860.231.0718 or HeadacheResearch@hhchealth.org.


Theranica Research StudyTheranica Study

Principle Investigator: Dr. Brian Grosberg

We are no longer recruiting for this study.

You may qualify to participate in a research study conducted at Hartford HealthCare Headache Center, of a home treatment for migraine using self-administered medical device. The study device is non-invasive and does not require taking medications. Compensation for your time and travel is available.

Frequently Asked Questions:

Q: What is the purpose of this study?
A: The clinical study is being conducted to test the effectiveness of an investigation device for the acute treatment of migraine in patients who suffer from chronic migraine.

Q: Am I eligible to participate?
A: To be eligible to participate in this study, you must be 18-75 years old and be diagnosed with chronic migraine.

Q: If am eligible and choose to participate, what will be my role in the study?
A: The investigational device is self-applied on the upper-arm and produces electrical stimulation in the nervous system that inhibits migraine headache. You will use the investigational device at home during an 8 week period and report you migraine attacks in your mobile phone diary app.

Q: Will I be paid for taking part in this research?
A: Qualified participants may receive:
     • An investigational drug-free non-invasive device at no cost
     • Compensation for time and travel

To participate, please contact the study team at 860.231.0718 or HeadacheResearch@hhchealth.org.

Headache Center