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Research & Clinical Trials

The following research studies and clinical trials are being conducted by the Headache Center.


Hartford HealthCare Headache Registry


Migraine Treatment with Nerivio Migra Neurostimulation Device

Sponsor: Theranica Bioelectronics Ltd.

Frequently Asked Questions

Q: What is the purpose of the study?
A: The purpose of this research study is to test an investigational armband device that provides nonpainful electrical stimulation for the treatment of migraine.

Q: Am I eligible to participate?
A:
To be eligible to participate in the study, you must have an average of 2-8 migraine attacks per month with no more than 14 total headache days per month. You will not be eligible to participate in the study if you are pregnant or breast-feeding.

Q: What will my participation in this study be like?
A:
If you are eligible and decide to participate in this study, you will first be randomized to one of two groups. One group will receive the active treatment device and the other group will receive a non-active control device. Neither you nor your provider will know which device you are receiving. The device is controlled via Android smartphone. If you do not have an Android smartphone, one will be provided to you for the duration of the study. Before you begin treatment with the Nerivio Migra device, you will first be asked to monitor your headaches for 1 month using an electronic diary on the smartphone. After one month of monitoring, you will then be asked to treat 4 migraine attacks or migraines during a 2 month period (whichever comes first). Your participation in the study will last 3-4 months. You will need to return the smartphone and armband device at the end of the study.

Q: How do I administer neurostimulation with the armband device?
A:
The armband device can be turned on using the smartphone application. The device delivers nonpainful electrical pulses to your skin for a period of 25 minutes. You will be able to adjust the strength of the pulses. You will be asked not to use any acute medication within 2 hours of treatment start with the Nerivio Migra device.

Q: What are the benefits to participating in this study?
A:
If you receive an active Nerivio Migra device and it proves to effectively treat your condition, you may experience reduced migraine pain and other symptoms throughout the course of the study. Additionally, information gained from this research could lead Nerivio Migra to help others in the future. In return for your time, effort, and travel expenses, you will be paid up to $200 for your participation in the study. The study is of no cost to you.


Status Migrainosus: Differentiating Between Responders and Non-responders in the Setup of Real-life Clinical Practice

Investigators: Dr. Rami Burstein, Beth Israel Deaconess Medical Center and Dr. Brian Grosberg, Hartford HealthCare Headache Center

Dr. Brian Grosberg, Medical Director of the Hartford HealthCare Headache Center, is co-winner of the Migraine Research Foundation's first Impact Award that will fund a 3-year study on Status Migrainosus.

To determine if you are eligible to participate in the status migrainosus study, you must first become a new patient of the Hartford HealthCare Headache Center. Click here to learn how to become a new patient.

Frequently Asked Questions

Q: What is “status migrainosus"?
A:
Status migrainosus is a severe form of migraine that lasts for 3 or more days.

Q: What is the status migrainosus study?
A:
The goal of the study is to explore how status migrainosus sufferers respond to different treatments and determine what treatments work best for different types of patients.

Q: If I am eligible and decide to participate, what will be my role in the study?
A:
There will be 4 parts to the study.

  • In part 1, you will have an interview about your headaches and complete a secure, online Headache Questionnaire if you have not done so already.
  • In part 2, you will receive a treatment that the headache specialist thinks will best treat your headaches. You will know what treatment you are receiving and will be involved in making this decision. At this visit, you will also be taught how to keep a detailed headache diary.
  • In part 3, you will complete headache diaries for 30 days. The diary for the first day will be by the hour and the rest of the diaries will be daily for the next 29 days.
  • In part 4, you will have another meeting with the headache specialist. During this meeting, you will be asked to explain your headache diaries in detail so that the headache specialist can figure out whether you have responded to treatment or not.

Q: How can my participation in this study help me and other migraine sufferers?
A:
By participating in this study, you can help take the “guess work” out of treating migraine that lasts continuously for 3 or more days. This may help to shorten and improve treatment for you and migraine sufferers worldwide.

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